| Autor: |
Julien Caillé, Paul Setzer, Fabien Boeda, Morwenna S. M. Pearson-Long, Philippe Bertus |
| Jazyk: |
angličtina |
| Rok vydání: |
2018 |
| Předmět: |
|
| Zdroj: |
SynOpen, Vol 02, Iss 01, Pp 0041-0049 (2018) |
| Druh dokumentu: |
article |
| ISSN: |
2509-9396 |
| DOI: |
10.1055/s-0036-1591933 |
| Popis: |
Abstract The titanium-catalyzed asymmetric cyclopropanation of cyanoesters with Grignard reagents was investigated for the first time. Particularly, the study of the efficiency of Taddol-based titanium complexes has shown that the prior preparation of Taddol titanium complexes was not required and a large panel of ligands was evaluated by using this approach. The spirocyclopropanelactams were obtained with good diastereoselectivity and with moderate enantioselectivities from the main diastereoisomer (up to 32%). |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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