| Autor: |
Amadeo Muñoz García, Juri Juksar, Nathalie Groen, Arnaud Zaldumbide, Eelco de Koning, Françoise Carlotti |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
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| Zdroj: |
Frontiers in Immunology, Vol 15 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
1664-3224 |
| DOI: |
10.3389/fimmu.2024.1381319 |
| Popis: |
IntroductionInflammation of the pancreas contributes to the development of diabetes mellitus. Although it is well-accepted that local inflammation leads to a progressive loss of functional beta cell mass that eventually causes the onset of the disease, the development of islet inflammation remains unclear.MethodsHere, we used single-cell RNA sequencing to explore the cell type-specific molecular response of primary human pancreatic cells exposed to an inflammatory environment.ResultsWe identified a duct subpopulation presenting a unique proinflammatory signature among all pancreatic cell types.DiscussionOverall, the findings of this study point towards a role for duct cells in the propagation of islet inflammation, and in immune cell recruitment and activation, which are key steps in the pathophysiology of diabetes mellitus. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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