T-cell leukemogenesis is an inappropriate lineage decision-making process: implications for precision oncology

Autor:	Guillermo Rodríguez-Hernández, Sanil Bhatia, Carolina Vicente-Dueñas, Arndt Borkhardt, Julia Hauer, Isidro Sánchez-García
Jazyk:	angličtina
Rok vydání:	2018
Předmět:	lmo2 notch1 stem cells cancer mouse models target cell cancer cell-of-origin cancer-stem-cell and tumor reprogramming Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Zdroj:	Molecular & Cellular Oncology, Vol 5, Iss 4 (2018)
Druh dokumentu:	article
ISSN:	2372-3556 23723556 64228819
DOI:	10.1080/23723556.2018.1497860
Popis:	Genetic lineage tracing in cell type-specific mouse models of T-cell acute lymphoblastic leukemia (T-ALL) have revealed that tumor cell identity is imposed by expression of the oncogene Lim Domain Only 2 (LMO2), rather than by the target cell phenotype. This approach allowed to identify that secondary genomic alterations, like Notch1 mutations, appeared late and only took place within the thymus during T-ALL development. These concepts are therefore critical for the development of modern therapies aimed at curing T-ALL.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/e57e34ff38b6422881995b7b42a3f771 Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.