Inhibition of negative feedback for persistent epithelial cell–cell junction contraction by p21-activated kinase 3

Autor: Hiroyuki Uechi, Kazuki Fukushima, Ryota Shirasawa, Sayaka Sekine, Erina Kuranaga
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-022-31252-0
Popis: Actin and myosin operate at cell–cell junctions during junctional shortening. Here the authors show that prolonged actomyosin contractility can compromise junctional shortening, and that Pak3 is required for attenuation of abnormal active protrusive structure and thus keeps junction contraction, appropriate E-cadherin distribution, and junction shortening in Drosophila.
Databáze: Directory of Open Access Journals