| Autor: |
Yasmine Y. Fathy, Dagmar H. Hepp, Frank J. de Jong, Jeroen J.G. Geurts, Elisabeth M.J. Foncke, Henk W. Berendse, Wilma D.J. van de Berg, Menno M. Schoonheim |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
NeuroImage: Clinical, Vol 28, Iss , Pp 102364- (2020) |
| Druh dokumentu: |
article |
| ISSN: |
2213-1582 |
| DOI: |
10.1016/j.nicl.2020.102364 |
| Popis: |
Background: The insula is a central brain hub involved in cognition and affected in Parkinson’s disease (PD). The aim of this study was to assess functional connectivity (FC) and betweenness centrality (BC) of insular sub-regions and their relationship with cognitive impairment in PD. Methods: Whole-brain 3D-T1, resting-state functional MRI and a battery of cognitive tests (CAMCOG) were included for 53 PD patients and 15 controls. The insular cortex was segmented into ventral (vAI) and dorsal (dAI) anterior and posterior sub-regions. Connectivity between insular sub-regions and resting-state networks was assessed and related to cognition; BC was used to further explore nodes associated with cognition. Results: Cognitive performance was significantly lower in PD patients compared to controls (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
