| Autor: |
Zuriel Shee Da En, Ervina Efzan Mhd Noor, Aminuddin Ahmed Kayani, Mohd Hazwan Hussin, Mirza Farrukh Baig |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
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| Zdroj: |
Bioengineering, Vol 11, Iss 7, p 698 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2306-5354 |
| DOI: |
10.3390/bioengineering11070698 |
| Popis: |
This study employs electrochemical impedance spectroscopy (EIS) to probe the behavior of Tau-441 protein, a key component implicated in Alzheimer’s disease. Through meticulous experimentation and analysis, the impedance of Tau-441 protein suspension revealed a conductivity peak value of 1.02 S/m. The study demonstrates a high level of specificity and selectivity, particularly within the challenging nanomolar concentration range. Additionally, the EIS method enabled the prediction of Tau-441 protein’s dielectrophoresis (DEP) response and the determination of the associated frequency range of 1 kHz to 1 MHz. These findings contribute to advancing our understanding of the molecular intricacies surrounding Tau-441 and hold promise for unraveling implications related to Alzheimer’s disease. This study establishes a robust foundation for future research on neurodegenerative disease and biosciences, offering valuable insights into the electrochemical dynamics of Tau-441 protein. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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