| Autor: |
Norihiro Okada, Kenshiro Oshima, Yuki Iwasaki, Akiko Maruko, Kenya Matsumura, Erica Iioka, Trieu-Duc Vu, Naoki Fujitsuka, Akinori Nishi, Aiko Sugiyama, Mitsue Nishiyama, Atsushi Kaneko, Kazushige Mizoguchi, Masahiro Yamamoto, Susumu Nishimura |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Data in Brief, Vol 42, Iss , Pp 108197- (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2352-3409 |
| DOI: |
10.1016/j.dib.2022.108197 |
| Popis: |
We performed RNA-seq analyses of mRNA isolated from five organs, liver, bone, heart, kidney and blood at the pre-symptomatic state of klotho mice with/without administration of a Japanese traditional herbal medicine, juzentaihoto (JTT). Data of differentially expressed genes (DEG) with/without JTT was included. Intron retention (IR) is an important regulatory mechanism that affects gene expression and protein functions. We collected data in which retained-introns were accumulated in a particular set of genes of these organs, and showed that among these retained introns in the liver and bone a subset was recovered to the normal state by the medicine. All of the data present changes of molecular events on the levels of metabolites, proteins and gene expressions observed at the pre- symptomatic state of aging in klotho mice with/without JTT. The research article related to this Data in Brief is published in GENE entitled as “Intron retention as a new pre-symptomatic marker of aging and its recovery to the normal state by a traditional Japanese herbal medicine”. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
