Autor: |
Mie Kobayashi-Ishihara, Yasuko Tsunetsugu-Yokota |
Jazyk: |
angličtina |
Rok vydání: |
2024 |
Předmět: |
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Zdroj: |
Viruses, Vol 16, Iss 5, p 666 (2024) |
Druh dokumentu: |
article |
ISSN: |
1999-4915 |
DOI: |
10.3390/v16050666 |
Popis: |
Human Immunodeficiency Virus type 1 (HIV-1) latency represents a significant hurdle in finding a cure for HIV-1 infections, despite tireless research efforts. This challenge is partly attributed to the intricate nature of HIV-1 latency, wherein various host and viral factors participate in multiple physiological processes. While substantial progress has been made in discovering therapeutic targets for HIV-1 transcription, targets for the post-transcriptional regulation of HIV-1 infections have received less attention. However, cumulative evidence now suggests the pivotal contribution of post-transcriptional regulation to the viral latency in both in vitro models and infected individuals. In this review, we explore recent insights on post-transcriptional latency in HIV-1 and discuss the potential of its therapeutic targets, illustrating some host factors that restrict HIV-1 at the post-transcriptional level. |
Databáze: |
Directory of Open Access Journals |
Externí odkaz: |
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