Exploring virulence in Mycobacterium bovis: clues from comparative genomics and perspectives for the future

Autor: Morgane Mitermite, Jose Maria Urtasun Elizari, Ruoyao Ma, Damien Farrell, Stephen V. Gordon
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Irish Veterinary Journal, Vol 76, Iss S1, Pp 1-9 (2023)
Druh dokumentu: article
ISSN: 2046-0481
DOI: 10.1186/s13620-023-00257-6
Popis: Abstract Here we provide a summary of a plenary lecture delivered on Mycobacterium bovis, the bovine TB bacillus, at the M. bovis 2022 meeting held in Galway, Ireland, in June 2022. We focus on the analysis of genetic differences between M. bovis and the human pathogen Mycobacterium tuberculosis as a route to gain knowledge on what makes M. bovis function as an animal pathogen. We provide a brief historical background around M. bovis and comparative virulence experiments with M. tuberculosis, before moving to what we have learned from the studies of the M. bovis genome sequence. We discuss the need to translate knowledge on the molecular basis of virulence in M. bovis into improved control of bovine tuberculosis.
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