[18F]NaF PET/CT as a Marker for Fibrodysplasia Ossificans Progressiva: From Molecular Mechanisms to Clinical Applications in Bone Disorders

Autor: Jolien Zwama, Neeltje M. Rosenberg, Vincent A. Verheij, Pieter G. H. M. Raijmakers, Maqsood Yaqub, Esmée Botman, Ruben D. de Ruiter, Mark R. Garrelfs, Arend Bökenkamp, Dimitra Micha, Lothar A. Schwarte, Bernd P. Teunissen, Adriaan A. Lammertsma, Ronald Boellaard, Elisabeth M. W. Eekhoff
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Biomolecules, Vol 14, Iss 10, p 1276 (2024)
Druh dokumentu: article
ISSN: 2218-273X
DOI: 10.3390/biom14101276
Popis: Fibrodysplasia ossificans progressiva (FOP) is a rare genetic bone disorder characterized by episodic flare-ups in connective tissue, which are frequently followed by the formation of heterotopic ossification. The absence of available plasma-soluble biomarkers for flare-ups or heterotopic bone formation poses severe challenges to the monitoring of disease activity to measure or predict disease progression. Recently, 18-fluor-sodium fluoride positron emission tomography/computed tomography ([18F]NaF PET/CT) was introduced as a potential marker for ossifying FOP activity. This review discusses the pharmacokinetics of [18F]NaF in relation to the pathophysiology of FOP, and its use as a marker of local bone metabolism in a variety of bone-related disorders. In addition, the review specifically addresses the applicability of [18F]NaF PET/CT imaging in FOP as a monitoring modality.
Databáze: Directory of Open Access Journals
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