Molecular effects of stable gastric pentadecapeptide BPC 157 on psoriasis
| Autor: | Hrvoje Vraneš, Luka Kalogjera, Ivan Maria Smoday |
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| Jazyk: | English<br />Croatian |
| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Liječnički vjesnik, Vol 145, Iss Supp 2, Pp 44-44 (2023) |
| Druh dokumentu: | article |
| ISSN: | 0024-3477 1849-2177 |
| DOI: | 10.26800/LV-145-supl2-BS07 |
| Popis: | Psoriasis is a chronic, relapsing, immune-mediated skin disease. Etiopathogeniesis of psoriasis includes pro-inflammatory cytokines such as: TNF-alpha, IL-12, IL-17, IL-23 etc. IL-17 exerts its effect by binding to IL-17R (Interleukin-17 receptor) on keratinocytes. Keratinocytes then in response produce β2-defensin. β-defensins have multiple antimicrobial and pro-inflammatory effects that are observed in psoriasis. Since stable gastric pentadecapeptide BPC 157 has shown anti-inflammatory effects in several studies, in this research we explored antiinflammatory effects of BPC 157 on molecular level in psoriasis. |
| Databáze: | Directory of Open Access Journals |
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