Dose omission to shorten methacholine challenge testing: clinical consequences of the use of a 10% fall in FEV1 threshold

Autor:	Valérie Lévesque, Claude Poirier, Bruno-Pierre Dubé
Jazyk:	angličtina
Rok vydání:	2018
Předmět:	Asthma Methacholine challenge testing Respiratory physiology Immunologic diseases. Allergy RC581-607
Zdroj:	Allergy, Asthma & Clinical Immunology, Vol 14, Iss 1, Pp 1-7 (2018)
Druh dokumentu:	article
ISSN:	1710-1492
DOI:	10.1186/s13223-018-0309-y
Popis:	Abstract Introduction In methacholine challenge testing (MCT), skipping a methacholine dose is suggested if FEV1 falls by 1 nebulized salbutamol dose (2.5 mg) to reach basal FEV1, palpitations; severe: hypoxemia and/or need for medical attention or intervention] were compared in the skip5–10% group and others. Regression analysis was used to identify predictors of AE. Results 208 MCTs were analysed (135 males, age 52 ± 15 years). Skip5–10% occurred 111 times in 90 tests. Prevalence of AE was 5% and all were mild. Patients who developed AEs had lower FEV1, FVC and FEV1/FVC ratio, and higher lung volume values (all p
Databáze:	Directory of Open Access Journals
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