Cost-effectiveness of freeze-all policy – A retrospective study based upon the outcome of cumulative live births

Autor: Jui-Chun Chang, Yu-Chiao Yi, Pao-sheng Shen, Hwa-Fen Guu, Ya-Fang Chen, Hsiao-Fan Kung, Li-Yu Chen, Ming-Jer Chen
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Taiwanese Journal of Obstetrics & Gynecology, Vol 60, Iss 1, Pp 125-131 (2021)
Druh dokumentu: article
ISSN: 1028-4559
DOI: 10.1016/j.tjog.2020.11.019
Popis: Object: We have previously reported that cumulative live birth rates (CLBRs) are higher in the freeze-all group compared with controls (64.3% vs. 45.8%, p = 0.001). Here, we aim to determine if the freeze-all policy is more cost-effective than fresh embryo transfer followed by frozen-thawed embryo transfer (FET). Materials and methods: The analysis consisted of 704 ART (Assisted reproductive technology) cycles, which included in IVF (In vitro fertilisation) and ICSI (Intra Cytoplasmic Sperm Injection) cycles performed in Taichung Veterans General Hospital, Taiwan between January 2012 and June 2014. The freeze-all group involved 84 patients and the fresh Group 625 patients. Patients were followed up until all embryos obtained from a single controlled ovarian hyper-stimulation cycle were used up, or a live birth had been achieved. The total cost related to treatment of each patient was recorded. The incremental cost-effectiveness ratio (ICER) was based on the incremental cost per couple and the incremental live birth rate of the freeze-all strategy compared with the fresh ET strategy. Probabilistic sensitivity analysis (PSA) and a cost-effectiveness acceptability curve (CEAC) were performed. Results: The total treatment cost per patient was significantly higher for the freeze-all group than in the fresh group (USD 3419.93 ± 638.13 vs. $2920.59 ± 711.08 p
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