Antitumor Research on Artemisinin and Its Bioactive Derivatives

Autor: Yunqin Zhang, Guowei Xu, Shuqun Zhang, Dong Wang, P. Saravana Prabha, Zhili Zuo
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: Natural Products and Bioprospecting, Vol 8, Iss 4, Pp 303-319 (2018)
Druh dokumentu: article
ISSN: 2192-2195
2192-2209
DOI: 10.1007/s13659-018-0162-1
Popis: Abstract Cancer is the leading cause of human death which seriously threatens human life. The antimalarial drug artemisinin and its derivatives have been discovered with considerable anticancer properties. Simultaneously, a variety of target-selective artemisinin-related compounds with high efficiency have been discovered. Many researches indicated that artemisinin-related compounds have cytotoxic effects against a variety of cancer cells through pleiotropic effects, including inhibiting the proliferation of tumor cells, promoting apoptosis, inducing cell cycle arrest, disrupting cancer invasion and metastasis, preventing angiogenesis, mediating the tumor-related signaling pathways, and regulating tumor microenvironment. More importantly, artemisinins demonstrated minor side effects to normal cells and manifested the ability to overcome multidrug-resistance which is widely observed in cancer patients. Therefore, we concentrated on the new advances and development of artemisinin and its derivatives as potential antitumor agents in recent 5 years. It is our hope that this review could be helpful for further exploration of novel artemisinin-related antitumor agents. Graphical Abstract
Databáze: Directory of Open Access Journals
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