Characterization of the Toxicological Impact of Heavy Metals on Human Health in Conjunction with Modern Analytical Methods

Autor: Dana Claudia Filipoiu, Simona Gabriela Bungau, Laura Endres, Paul Andrei Negru, Alexa Florina Bungau, Bianca Pasca, Andrei-Flavius Radu, Alexandra Georgiana Tarce, Mihaela Alexandra Bogdan, Tapan Behl, Aurelia Cristina Nechifor, Syed Shams ul Hassan, Delia Mirela Tit
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Toxics, Vol 10, Iss 12, p 716 (2022)
Druh dokumentu: article
ISSN: 2305-6304
DOI: 10.3390/toxics10120716
Popis: Increased environmental pollution, urbanization, and a wide variety of anthropogenic activities have led to the release of toxic pollutants into the environment, including heavy metals (HMs). It has been found that increasing concentrations of HMs lead to toxicity, mineral imbalances, and serious diseases, which are occurring more and more frequently. Therefore, testing has become imperative to detect these deficiencies in a timely manner. The detection of traces of HMs, especially toxic ones, in human tissues, various biological fluids, or hair is a complex, high-precision analysis that enables early diagnosis, addressing people under constant stress or exposed to a toxic environment; the test also targets people who have died in suspicious circumstances. Tissue mineral analysis (TMA) determines the concentration of toxic minerals/metals at the intracellular level and can therefore determine correlations between measured concentrations and imbalances in the body. Framing the already-published information on the topic, this review aimed to explore the toxicity of HMs to human health, the harmful effects of their accumulation, the advantages vs. the disadvantages of choosing different biological fluids/tissues/organs necessary for the quantitative measurement of HM in the human body, as well as the choice of the optimal method, correlated with the purpose of the analysis.
Databáze: Directory of Open Access Journals