Cardiac biopsies reveal differences in transcriptomics between left and right ventricle in patients with or without diagnostic signs of heart failure

Autor:	Christoffer Frisk, Sarbashis Das, Maria J. Eriksson, Anna Walentinsson, Matthias Corbascio, Camilla Hage, Chanchal Kumar, Mattias Ekström, Eva Maret, Hans Persson, Cecilia Linde, Bengt Persson
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	Heart failure Ischemic heart disease Cardiac biopsy Left ventricular dysfunction Gene expression Medicine Science
Zdroj:	Scientific Reports, Vol 14, Iss 1, Pp 1-17 (2024)
Druh dokumentu:	article
ISSN:	2045-2322
DOI:	10.1038/s41598-024-56025-1
Popis:	Abstract New or mild heart failure (HF) is mainly caused by left ventricular dysfunction. We hypothesised that gene expression differ between the left (LV) and right ventricle (RV) and secondly by type of LV dysfunction. We compared gene expression through myocardial biopsies from LV and RV of patients undergoing elective coronary bypass surgery (CABG). Patients were categorised based on LV ejection fraction (EF), diastolic function and NT-proBNP into pEF (preserved; LVEF ≥ 45%), rEF (reduced; LVEF
Databáze:	Directory of Open Access Journals
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