FT3/FT4 ratio predicts non-alcoholic fatty liver disease independent of metabolic parameters in patients with euthyroidism and hypothyroidism

Autor: Fatma Yahyaoğlu Gökmen, Süleyman Ahbab, Hayriye Esra Ataoğlu, Betül Çavuşoğlu Türker, Faik Çetin, Fatih Türker, Rabia Yahyaoğlu Mamaç, Mustafa Yenigün
Jazyk: angličtina
Rok vydání: 2016
Předmět:
Zdroj: Clinics, Vol 71, Iss 4, Pp 221-225 (2016)
Druh dokumentu: article
ISSN: 1980-5322
DOI: 10.6061/clinics/2016(04)08
Popis: OBJECTIVE: This study was performed to evaluate the effects of metabolic parameters and thyroid dysfunction on the development of non-alcoholic fatty liver disease (NAFLD). METHODS: The current study evaluated a total of 115 patients, 75 female and 40 male. Physical examination and anthropometric measurements were applied to all participants. Hypothyroidism was considered at a thyroid stimulating hormone level ≥ 4.1 mIU/L. Patients with euthyroidism and patients with hypothyroidism were compared. Abdominal ultrasonography was used to diagnose non-alcoholic fatty liver disease. The participants were further compared with regard to the presence of non-alcoholic fatty liver disease. Logistic regression modeling was performed to identify the relationship between non-alcoholic fatty liver disease and independent variables, such as metabolic parameters and insulin resistance. RESULTS: Non-alcoholic fatty liver disease was identified in 69 patients. The mean waist circumference, body mass index, fasting plasma insulin, HOMA-IR (p
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