Clinical and laboratory risk factors for sickle cell retinopathy and maculopathy: a scoping review of the current evidence
| Autor: | Rajani P. Brandsen, Roselie M.H. Diederen, Gizem Kocabas, Erfan Nur, Arjan Malekzadeh, Reinier O. Schlingemann, Bart J. Biemond |
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| Jazyk: | angličtina |
| Rok vydání: | 2024 |
| Předmět: | |
| Zdroj: | Haematologica, Vol 999, Iss 1 (2024) |
| Druh dokumentu: | article |
| ISSN: | 0390-6078 1592-8721 |
| DOI: | 10.3324/haematol.2024.286420 |
| Popis: | Sickle cell retinopathy (SCR) is a complication of sickle cell disease (SCD) and can drastically impair visual acuity. Screening for SCR is therefore recommended, but evidence for optimal screening frequency on an individual level is lacking. This scoping review mapped the current evidence on risk factors for SCR and sickle cell maculopathy (SCM). A literature search (in Medline(Ovid), Embase(Ovid) and Scopus) resulted in 67 included articles, which covered demographic risk factors, genetic risk factors, systemic therapy, correlations with other forms of SCD-related organ damage and hematological risk factors. SCR risk factors include older age, male sex, HbSC genotype, hemolysis and HbF% 15%) patients to ensure comprehensive yet proportionate ophthalmic care. However, to elucidate the sense and nonsense of screening, future studies are needed on the role of interventions for SCR and the long-term consequences of SCM. |
| Databáze: | Directory of Open Access Journals |
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