Cytotoxic Activities and Fingerprint Analysis of Triterpenes by HPTLC Technique for Distinguishing Ganoderma Species from Vietnam and other Asian Countries

Autor: Tran Viet Hung, Phan Nguyen Truong Thang, Ha Minh Hien, Vu Thi Diep, Nguyen Thi Thu, Duong Minh Tan, Duy Toan Pham, Do Thi Ha, Duyen Thi My Huynh
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Plants, Vol 11, Iss 23, p 3397 (2022)
Druh dokumentu: article
ISSN: 11233397
2223-7747
DOI: 10.3390/plants11233397
Popis: Ganoderma lucidum (Fr.) P. Karst. (Ganodermataceae), commonly called Linhzhi, is traditionally employed in the treatment of human diseases, including hepatitis, liver disorders, hypercholesterolemia, arthritis, bronchitis, and tumorigenic diseases. In this study, the fingerprint profiles of five different strains of G. lucidum originated from Japan, Korea, China, and Vietnam, five samples of G. lucidum growing on Erythrophloeum fordii Oliv. in Vietnam, and five related Linhzhi species (Ganoderma applanatum, Ganoderma australe, Ganoderma clossum, Ganoderma subresinosu, and Ganoderma sp.) were investigated for triterpene derivatives using high-pressure, thin-layer chromatography (HPTLC). The HPTLC fingerprint profiles demonstrated significant differences between G. lucidum and other related Linhzhi species in the presence of triterpene derivatives. Evaluation for the cytotoxicity of these samples against four cancer cell lines, including A549, MCF7, PC3, and HepG2, displayed various levels of cytotoxic effects, with IC50 values of: 15.6–46.3 µg/mL on the A549 cancer cell line, of 18.4–43.6 µg/mL on the MCF7 cancer cell line, of 10.0–32.1 µg/mL on the PC3 cancer cell line, and of 10.6–27.6 µg/mL on the HepG2 cancer cell line. Conclusively, these data contributed to the literature on the cytotoxic activities and fingerprint analysis of triterpenes by the HPTLC technique for distinguishing Ganoderma species from Vietnam and other Asian countries.
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