A Comparative Study of Mesenchymal Stem Cell-Derived Extracellular Vesicles’ Local and Systemic Dose-Dependent Administration in Rat Spinal Cord Injury

Autor: Alexander Kostennikov, Ilyas Kabdesh, Davran Sabirov, Anna Timofeeva, Alexander Rogozhin, Ilya Shulman, Albert Rizvanov, Yana Mukhamedshina
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Biology, Vol 11, Iss 12, p 1853 (2022)
Druh dokumentu: article
ISSN: 2079-7737
DOI: 10.3390/biology11121853
Popis: Spinal cord injury (SCI) is a serious neurological condition that causes severe disability. One of the approaches to overcoming the complications of SCI is stem cell-derived extracellular vesicle (EV) therapy. In this research, we performed a comparative evaluation of rat spinal cord post-traumatic regeneration efficacy using different methods of mesenchymal stem cell-derived EV transplantation (local vs. systemic) followed by evaluation of their minimal therapeutic dose. The results suggested that MSC-EV therapy could improve locomotor activity over 60 days after the SCI, showing a dose-dependent effect on the recovery of spinal cord motor pathways. We also established the possibility of maintaining a population of mature oligodendrocytes by MSC-EVs. It was observed that in the spinal cord injury area, intravenous transplantation of MSC-EVs showed more pronounced therapeutic effects compared to the treatment of fibrin matrix-encapsulated MSC-EVs.
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