Effects of Melatonin and Epiphyseal Proteins on Fluoride-Induced Adverse Changes in Antioxidant Status of Heart, Liver, and Kidney of Rats
| Autor: | Vijay K. Bharti, R. S. Srivastava, H. Kumar, S. Bag, A. C. Majumdar, G. Singh, S. R. Pandi-Perumal, Gregory M. Brown |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: | |
| Zdroj: | Advances in Pharmacological Sciences, Vol 2014 (2014) |
| Druh dokumentu: | article |
| ISSN: | 1687-6334 1687-6342 |
| DOI: | 10.1155/2014/532969 |
| Popis: | Several experimental and clinical reports indicated the oxidative stress-mediated adverse changes in vital organs of human and animal in fluoride (F) toxicity. Therefore, the present study was undertaken to evaluate the therapeutic effect of buffalo (Bubalus bubalis) epiphyseal (pineal) proteins (BEP) and melatonin (MEL) against F-induced oxidative stress in heart, liver, and kidney of experimental adult female rats. To accomplish this experimental objective, twenty-four adult female Wistar rats (123–143 g body weights) were divided into four groups, namely, control, F, F + BEP, and F + MEL and were administered sodium fluoride (NaF, 150 ppm elemental F in drinking water), MEL (10 mg/kg BW, i.p.), and BEP (100 µg/kg BW, i.p.) for 28 days. There were significantly P |
| Databáze: | Directory of Open Access Journals |
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