Functions of IgM fc receptor (FcµR) related to autoimmunity

Autor: Hiromi Kubagawa, Pedram Mahmoudi Aliabadi, Khlowd Al-Qaisi, Peter K. Jani, Kazuhito Honjo, Shozo Izui, Andreas Radbruch, Fritz Melchers
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Autoimmunity, Vol 57, Iss 1 (2024)
Druh dokumentu: article
ISSN: 08916934
1607-842X
0891-6934
DOI: 10.1080/08916934.2024.2323563
Popis: Unlike Fc receptors for switched immunoglobulin (Ig) isotypes, Fc receptor for IgM (FcµR) is selectively expressed by lymphocytes. The ablation of the FcµR gene in mice impairs B cell tolerance as evidenced by concomitant production of autoantibodies of IgM and IgG isotypes. In this essay, we reiterate the autoimmune phenotypes observed in mutant mice, ie IgM homeostasis, dysregulated humoral immune responses including autoantibodies, and Mott cell formation. We also propose the potential phenotypes in individuals with FCMR deficiency and the model for FcµR-mediated regulation of self-reactive B cells.
Databáze: Directory of Open Access Journals
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