PD-L1 expression in the microenvironment and the response to checkpoint inhibitors in head and neck squamous cell carcinoma

Autor:	D. Evrard, M. Hourseau, A. Couvelard, V. Paradis, H. Gauthier, E. Raymond, C. Halimi, B. Barry, S. Faivre
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	head and neck squamous cell carcinoma immune checkpoint inhibitors anti-pd-1/pd-l1 biomarkers tumor microenvironment Immunologic diseases. Allergy RC581-607 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Zdroj:	OncoImmunology, Vol 9, Iss 1 (2020)
Druh dokumentu:	article
ISSN:	2162-402X 2162402X
DOI:	10.1080/2162402X.2020.1844403
Popis:	In head and neck squamous cell carcinoma (HNSCC), data from studies using checkpoint-inhibiting antibodies that target programmed death 1 (PD-1) or its ligand the programmed death ligand 1 (PD-L1) demonstrated outstanding clinical activity. Translational investigations also suggested some correlations between therapeutic response and PD-L1 expression in tumor tissue. We comprehensively summarize results that have evaluated PD-L1 expression in HNSCC. We discuss flaws and strength of current PD-1/PD-L1 detection, quantification methods and the evaluation of PD-L1 as a prognostic and theragnostic biomarker. Understanding tumor microenvironment may help understanding resistance to checkpoint inhibitors, designing clinical trials that can exploit drug combinations.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/571e4cb9d8c8414cbc7ee78a130c9abc Zobrazit plný text záznamu View record in DOAJ