Autor: |
Jacqueline Hernandez, Javier A. Tamargo, Sabrina Sales Martinez, Haley R. Martin, Adriana Campa, Rafick-Pierre Sékaly, Rebeka Bordi, Kenneth E. Sherman, Susan D. Rouster, Heidi L. Meeds, Jag H. Khalsa, Raul N. Mandler, Shenghan Lai, Marianna K. Baum |
Jazyk: |
angličtina |
Rok vydání: |
2022 |
Předmět: |
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Zdroj: |
PLoS ONE, Vol 17, Iss 10 (2022) |
Druh dokumentu: |
article |
ISSN: |
1932-6203 |
Popis: |
Objective Determine if cocaine use impacts gut permeability, promotes microbial translocation and immune activation in people living with HIV (PLWH) using effective antiretroviral therapy (ART). Methods Cross-sectional analysis of 100 PLWH (ART ≥6 months, HIV-RNA Results A total of 37 cocaine users and 63 cocaine non-users were evaluated. Cocaine users had higher levels of I-FABP (7.92±0.35 vs. 7.69±0.56 pg/mL, P = 0.029) and LPS (0.76±0.24 vs. 0.54±0.27 EU/mL, PConclusions Cocaine use was associated with markers of gut permeability, microbial translocation, and immune activation in virally suppressed PLWH. Mitigation of cocaine use may prevent further gastrointestinal damage and immune activation in PLWH. |
Databáze: |
Directory of Open Access Journals |
Externí odkaz: |
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