The Protective Effect of Artemisia spicigera Ethanolic Extract against Cryptosporidium parvum Infection in Immunosuppressed Mice
| Autor: | Parisa Shahbazi, Ahmad Nematollahi, Sanaz Arshadi, Hosein Hashemzadeh Farhang, Amir Ali Shahbazfar |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Iranian Journal of Parasitology, Vol 16, Iss 2 (2021) |
| Druh dokumentu: | article |
| ISSN: | 1735-7020 2008-238X |
| DOI: | 10.18502/ijpa.v16i2.6318 |
| Popis: | Background: A specific treatment has not yet developed for cryptosporidiosis, and some of the used drugs had side effects in immunodeficient patients. The goal of an appropriate remedy is to remove symptoms and improve immune responses in hosts. The current study was designed to evaluate the therapeutic efficacy of Artemisia spicigera ethanolic extract in experimentally infected immunosuppressed mice. Methods: Thirty six NMRI mice, 4-6 wk old, were randomly divided into six equal groups. C1: uninfected, treated control; C2: infected, untreated control; T1, T2, T3, and P: infected, treated with 0.2, 2, and 20 mg/ml extract, and 5mg/ml paromomycin, respectively. Mice were experimentally infected by oral administration of 104 oocysts/animal of Cryptosporidium parvum and treated orally for eight days per 12h, starting 12h before experimental infection. The presence of oocyst shedding, weight gain/loss, and the histopathology of ileum sections were examined. Results: Results revealed that oocyst shedding was significantly (P |
| Databáze: | Directory of Open Access Journals |
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