The Effect of Insulin Like Growth Factor-1 on Recovery of Facial Nerve Crush Injury
| Autor: | Asuman Feda Bayrak, Yuksel Olgun, Ayla Ozbakan, Safiye Aktas, Can Ahmet Kulan, Gonca Kamaci, Emine Demir, Osman Yilmaz, Levent Olgun |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: | |
| Zdroj: | Clinical and Experimental Otorhinolaryngology, Vol 10, Iss 4, Pp 296-302 (2017) |
| Druh dokumentu: | article |
| ISSN: | 1976-8710 2005-0720 |
| DOI: | 10.21053/ceo.2016.00997 |
| Popis: | Objectives The aim of this study is to investigate the efficacy of locally applied insulin-like growth factor 1 (IGF-1) on the recovery of facial nerve functions after crush injury in a rabbit model. Methods The rabbits were randomly assigned into three groups. Group 1 consisted of the rabbits with crush injury alone; group 2, the animals applied saline solution onto the crushed facial nerve and group 3, IGF-1 implemented to the nerve in the same manner. Facial nerve injury was first electrophysiologically studied on 10th and 42nd days of the procedure. The damage to the facial nerves was then investigated histopathologically, after sacrification of the animals. Results In the electrophysiological study, compound muscle action potential amplitudes of the crushed nerves in the second group were decreased. In pathological specimens of the first and second groups, the orders of axons were distorted; demyelination and proliferation of Schwann cells were observed. However, in IGF-1 treated group axonal order and myelin were preserved, and Schwann cell proliferation was close to normal (P |
| Databáze: | Directory of Open Access Journals |
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