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Introduction: Traditional healers' assertions that Quercus leucotrichophora A. Camus is a plant that has been used in traditional medicine to treat various urinary and renal diseases, thus the present study aims to investigate the diuretic activity of the methanolic extract of seeds in rats. Methods: Dried course powder was extracted with methanol using soxhlet extraction. Male Wistar rats were given a control (normal saline, 15 ml), a reference medication (furosemide, 13 mg/kg), and three separate doses (250 mg/kg, 375 mg/kg, and 500 mg/kg) of the extract orally. Urine volume, urinary electrolytes, urine pH, and conductivity were measured to establish the extract's diuretic activity. The urine outflow was tested at 6, 12, and 24 h, as well as electrolyte content, pH, and conductivity. Creatinine, urea, aldosterone, and electrolyte concentrations in plasma and urine samples were also determined. The index kidney function was determined by analyzing kidney homogenate. One-way ANOVA was used to evaluate the data. Results: The findings demonstrated that the extract increased diuresis in a dose-dependent manner, i.e., at 500 mg/kg, the extract exhibited significant diuretic effects (p |
