Autor: |
Alexia Nathália Brígido Assef, Bianca Barros da Costa, Thamyris Almeida Moreira, Luana David do Carmo, Tamiris de Fátima Goebel de Souza, Nylane Maria Nunes Alencar, Ana Paula Negreiros Nunes Alves, Leonardo Paes Cinelli, Diego Veras Wilke |
Jazyk: |
angličtina |
Rok vydání: |
2021 |
Předmět: |
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Zdroj: |
Carbohydrate Polymer Technologies and Applications, Vol 2, Iss , Pp 100142- (2021) |
Druh dokumentu: |
article |
ISSN: |
2666-8939 |
DOI: |
10.1016/j.carpta.2021.100142 |
Popis: |
Sulfated polysaccharides (SP) are a complex group of bioactive molecules able to inhibit tumor growth. SP increase the effectiveness of chemotherapy and reduce some side effects. Brown algae produce SP with several biological activities including antitumor. This work aimed to investigate the antitumor effect of SP from the brown algae Dictyota caribaea (Dc-SP). The chemical analyses demonstrated Dc-SP composition was mainly hexose, uronic acid, and sulfate. Dc-SP did not exhibit cytotoxicity against tumor cells in vitro. However, Dc-SP-treated mice with 25 and 50 mg/kg/day depicted Sarcoma 180 tumor growth inhibition of 40% (p |
Databáze: |
Directory of Open Access Journals |
Externí odkaz: |
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