Activating and inactivating mutations of the human, rat, equine and eel luteinizing hormone/ chorionic gonadotropin receptors (LH/CGRs)
| Autor: | Kwan-Sik Min, Munkhzaya Byambaragchaa, Seung-Hee Choi, Hyo-Eun Joo, Sang-Gwon Kim, Yean-Ji Kim, Gyeong-Eun Park |
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| Jazyk: | English<br />Korean |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Journal of Animal Reproduction and Biotechnology, Vol 36, Iss 4, Pp 167-174 (2021) |
| Druh dokumentu: | article |
| ISSN: | 2671-4639 2671-4663 |
| DOI: | 10.12750/JARB.36.4.169 |
| Popis: | Mutations in the luteinizing hormone/chorionic gonadotropin receptors (LH/CGRs), representatives of the G protein-coupled receptor family, have been rapidly identified over the last 20 years. This review aims to compare and analyze the data reported the activating and inactivating mutations of the LH/CGRs between human, rat, equine and fish, specifically (Japanese eel Anguilla japonica). Insights obtained through detailed study of these naturally-occurring mutations provide a further update of structure-function relationship of these receptors. Specifically, we present a variety of data on eel LH/CGR. These results provide important information about LH/CGR function in fish and the regulation of mutations of the highly conserved amino acids in glycoprotein hormone receptors. |
| Databáze: | Directory of Open Access Journals |
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