Predictors of quality of life, functional status, depression and fatigue in early arthritis: comparison between clinically suspect arthralgia, unclassified arthritis and rheumatoid arthritis

Autor: Barbara Torlinska, Karim Raza, Andrew Filer, Gurpreet Jutley, Ilfita Sahbudin, Ruchir Singh, Paola de Pablo, Elizabeth Rankin, Benjamin Rhodes, Nicole Amft, Elizabeth Justice, Catherine McGrath, Sangeetha Baskar, Jeanette Trickey, Melanie Calvert, Marie Falahee
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: BMC Musculoskeletal Disorders, Vol 25, Iss 1, Pp 1-11 (2024)
Druh dokumentu: article
ISSN: 1471-2474
DOI: 10.1186/s12891-024-07446-6
Popis: Abstract Background Rheumatoid arthritis (RA) is often preceded by symptomatic phases during which classification criteria are not fulfilled. The health burden of these “at-risk” stages is not well described. This study assessed health-related quality of life (HRQoL), function, fatigue and depression in newly presenting patients with clinically suspect arthralgia (CSA), unclassified arthritis (UA) or RA. Methods Cross-sectional analysis of baseline Patient-Reported Outcome Measures (PROMs) was conducted in patients from the Birmingham Early Arthritis Cohort. HRQoL, function, depression and fatigue at presentation were assessed using EQ-5D, HAQ-DI, PHQ-9 and FACIT-F. PROMs were compared across CSA, UA and RA and with population averages from the HSE with descriptive statistics. Multivariate linear regression assessed associations between PROMs and clinical and sociodemographic variables. Results Of 838 patients included in the analysis, 484 had RA, 200 had CSA and 154 had UA. Patients with RA reported worse outcomes for all PROMs than those with CSA or UA. However, “mean EQ-5D utilities were 0.65 (95%CI: 0.61 to 0.69) in CSA, 0.61 (0.56 to 0.66) in UA and 0.47 (0.44 to 0.50) in RA, which was lower than in general and older (≥ 65 years) background populations.” In patients with CSA or UA, HRQoL was comparable to chronic conditions such as heart failure, severe COPD or mild angina. Higher BMI and older age (≥ 60 years) predicted worse depression (PHQ-9: -2.47 (-3.85 to -1.09), P
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