Perforin-2 clockwise hand-over-hand pre-pore to pore transition mechanism

Autor: Fang Jiao, François Dehez, Tao Ni, Xiulian Yu, Jeremy S. Dittman, Robert Gilbert, Christophe Chipot, Simon Scheuring
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-022-32757-4
Popis: Direct visualization of the structural transformation from pre-pore to pore of the mammalian immune defense complex perforin-2 (PFN2) reveals a clockwise hand-over-hand mechanism that propagates at ~15 subunits per second.
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