Serum vascular endothelial growth factor affects tissue fluid accumulation and is associated with deteriorating tissue perfusion and oxygenation in severe sepsis: a prospective observational study

Autor: Chin-Kuo Lin, Ying-Huang Tsai, Kuo-Chin Kao, Chieh-Mo Lin, Shao-Kui Zhou, Meng-Chin Ho, Shu-Yi Huang, Yu-Hung Fang, Che-Chia Chang, Wei-Chun Lee, Yueh-Lin Lee, Min-Chi Chen, Meng-Jer Hsieh, Yu-Ching Lin, Ming-Szu Hung, Wen-Chun Kuo, Bor-Shyh Lin
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: European Journal of Medical Research, Vol 28, Iss 1, Pp 1-12 (2023)
Druh dokumentu: article
ISSN: 2047-783X
DOI: 10.1186/s40001-023-01119-1
Popis: Abstract Background Positive fluid balance and tissue fluid accumulation are associated with adverse outcomes in sepsis. Vascular endothelial growth factor (VEGF) increases in sepsis, promotes vascular permeability, and may affect tissue fluid accumulation and oxygenation. We used near-infrared spectroscopy (NIRS) to estimate tissue hemoglobin (Hb) oxygenation and water (H2O) levels to investigate their relationship with serum VEGF levels. Material and methods New-onset severe sepsis patients admitted to the intensive care unit were enrolled. Relative tissue concentrations of oxy-Hb ([HbO 2 ]), deoxy-Hb ([HbR]), total Hb ([HbT]), and H2O ([H 2 O]) were estimated by near-infrared spectroscopy (NIRS) for three consecutive days and serum VEGF levels were measured. Comparisons between oliguric and non-oliguric patients were conducted and the correlations between variables were analyzed. Results Among 75 eligible patients, compared with non-oliguric patients, oliguric patients were administrated more intravascular fluids (median [IQR], 1926.00 [1348.50–3092.00] mL/day vs. 1069.00 [722.00–1486.75] mL/day, p
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