Effect of arginine vasopressin on the canine epicardial coronary artery: experiments on V1-receptor-mediated production of nitric oxide

Autor:	Paulo Roberto B. Evora, Paul J. Pearson, Alfredo J. Rodrigues, Fernanda Viaro, Hartzell V. Schaff
Jazyk:	English<br />Portuguese
Rok vydání:	2003
Předmět:	coronary artery vasopressin endothelium nitric oxide Diseases of the circulatory (Cardiovascular) system RC666-701
Zdroj:	Arquivos Brasileiros de Cardiologia, Vol 80, Iss 5, Pp 489-494 (2003)
Druh dokumentu:	article
ISSN:	0066-782X 1678-4170
DOI:	10.1590/S0066-782X2003000500002
Popis:	OBJECTIVE: To determine whether arginine vasopressin releases endothelium-derived nitric oxide (EDNO) from the epicardial coronary artery. METHODS: We studied segments of canine left circumflex coronary arteries suspended in organ chambers to measure isometric force. The coronary artery segments were contracted with prostaglandin F2alpha (2 x 10-6M) and exposed to a unique, strong arginine vasopressin concentration (10-6M) or titrated concentrations (10-9 a 10-5 M). RESULTS: The unique dose of arginine vasopressin concentration (10-6M) induced transient, but significant (p
Databáze:	Directory of Open Access Journals
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