| Autor: |
Wellington Pham, Shawn Barton, Bo Li, Michael Siuta, Vaibhav A. Janve, Jessica Song, Clinton M. Holt, Takumi Tomono, Masami Ukawa, Hironori Kumagai, Etsuo Tobita, Kevin Wilson, Shinji Sakuma |
| Jazyk: |
angličtina |
| Rok vydání: |
2018 |
| Předmět: |
|
| Zdroj: |
Precision Nanomedicine, Vol 1, Iss 3 (2018) |
| Druh dokumentu: |
article |
| ISSN: |
2639-9431 |
| DOI: |
10.33218/prnano1(3).181009.1 |
| Popis: |
The Thomsen-Friedenreich (TF) antigen is a tumor-associated antigen consistently expressed on the apical surface of epithelial-based cancer cells, including pancreatic cancer. In this work, we report the development of multimodal imaging probe, the tripolymer fluorescent nanospheres, whose surface was fabricated with peanut agglutinin (PNA) moieties as TF molecular recognition molecules. Here, we demonstrate that the probe is able to detect TF antigen in human pancreatic cancer tissues and differentiate from normal tissue. What is most noteworthy regarding the probe is its ability to visualize tumor margins defined by epithelial TF antigen expression. Further, in vivo preclinical studies using an orthotopic mouse model of pancreatic cancer suggest the potential use of the nanospheres for laparoscopic imaging of pancreatic cancer tumor margins to enhance surgical resection and improve clinical outcomes. [READ ARTICLE](https://precisionnanomedicine.com/article/6495) |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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