A novel lncRNA Discn fine-tunes replication protein A (RPA) availability to promote genomic stability

Autor: Lin Wang, Jingzheng Li, Hu Zhou, Weidao Zhang, Jing Gao, Ping Zheng
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-021-25827-6
Popis: Various lncRNAs functions have been associated to replication stress and DNA double strand breaks in ESC. Here the authors reveal the lncRNA Discn-NCL-RPA axis pathway, which can regulate the availability of RPA pool for DNA replication stress response and repair.
Databáze: Directory of Open Access Journals