First report of concomitant cryptococcal meningitis and anti-NMDAR encephalitis

Autor: Sofia R. Valdoleiros, Margarida Calejo, António Marinho, Ana Martins da Silva, Olga Vasconcelos, Maria João Gonçalves, Rui Sarmento e Castro
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Brain, Behavior, & Immunity - Health, Vol 2, Iss , Pp 100036- (2020)
Druh dokumentu: article
ISSN: 2666-3546
DOI: 10.1016/j.bbih.2020.100036
Popis: Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is an autoimmune disorder, seen most often in young adults and children, triggered by tumors or infections. We report a case of cryptococcal meningitis in a patient with sarcoidosis, presenting prominent neuropsychiatric symptoms, electroencephalographic features of autoimmune encephalitis and positive anti-NMDAR antibodies in the cerebrospinal fluid, raising the hypothesis of an infectious immune-mediated mechanism triggering the production of anti-NMDAR antibodies. Since anti-NMDAR encephalitis is potentially fatal and has significant morbidity, further descriptions of its etiological associations are essential to early identification and prompt treatment.
Databáze: Directory of Open Access Journals