Excitatory and inhibitory synapses show a tight subcellular correlation that weakens over development

Autor: Sally Horton, Vincenzo Mastrolia, Rachel E. Jackson, Sarah Kemlo, Pedro M. Pereira Machado, Maria Alejandra Carbajal, Robert Hindges, Roland A. Fleck, Paulo Aguiar, Guilherme Neves, Juan Burrone
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Cell Reports, Vol 43, Iss 7, Pp 114361- (2024)
Druh dokumentu: article
ISSN: 2211-1247
DOI: 10.1016/j.celrep.2024.114361
Popis: Summary: Neurons receive correlated levels of excitation and inhibition, a feature that is important for proper brain function. However, how this relationship between excitatory and inhibitory inputs is established during the dynamic period of circuit wiring remains unexplored. Using multiple techniques, including in utero electroporation, electron microscopy, and electrophysiology, we reveal a tight correlation in the distribution of excitatory and inhibitory synapses along the dendrites of developing CA1 hippocampal neurons. This correlation was present within short dendritic stretches (
Databáze: Directory of Open Access Journals