Subretinal Coapplication of Tissue Plasminogen Activator and Bevacizumab with Concurrent Pneumatic Displacement for Submacular Hemorrhages Secondary to Neovascular Age-Related Macular Degeneration
| Autor: | Remzi Avcı, Ayşegül Mavi Yıldız, Esat Çınar, Sami Yılmaz, Cem Küçükerdönmez, Fatma Duriye Akalp, Emre Avcı |
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| Jazyk: | English<br />Turkish |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Türk Oftalmoloji Dergisi, Vol 51, Iss 1, Pp 38-44 (2021) |
| Druh dokumentu: | article |
| ISSN: | 1300-0659 2147-2661 |
| DOI: | 10.4274/tjo.galenos.2020.72540 |
| Popis: | Objectives:To evaluate the functional and morphological outcomes of vitrectomy in combination with intravitreal 5% C3F8 tamponade and subretinal injections of tissue plasminogen activator (tPA) and anti-vascular endothelial growth factor (anti-VEGF) in patients with submacular hemorrhage (SMH) and to investigate the preoperative prognostic factors.Materials and Methods:This retrospective study included 30 patients (16 women, 14 men) diagnosed with SMH secondary to neovascular age-related macular degeneration (AMD). Preoperative SMH thickness and area, ellipsoid zone integrity, and postoperative reduction in the amount of subfoveal blood on optical coherence tomography and fundus photographs were assessed. Furthermore, visual acuity (VA), hemorrhage duration, and the need for additional intravitreal anti-VEGF injections were recorded.Results:The patients’ mean age was 73.33±8.23 years. Mean VA improved from logMAR 2.11±0.84 at baseline to logMAR 1.32±0.91, 0.94±0.66, 1.13±0.84, and 1.00±0.70 at postoperative month 1, 2, 3, and 6, respectively. A significant negative correlation was found between hemorrhage duration and postoperative VA at month 2 (p=0.005), month 3 (p=0.019), and month 6 (p=0.012). The mean preoperative SMH duration was significantly shorter in patients who achieved total resolution of the hemorrhage compared with the subtotal resolution group (p |
| Databáze: | Directory of Open Access Journals |
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