| Autor: |
Cui-Ping Xing, Dan Chen, Chun-Lan Xie, Qingmei Liu, Tian-Hua Zhong, Zongze Shao, Guangming Liu, Lian-Zhong Luo, Xian-Wen Yang |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Marine Drugs, Vol 19, Iss 4, p 224 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
1660-3397 |
| DOI: |
10.3390/md19040224 |
| Popis: |
Ten new (1–10) and 26 known (11–36) compounds were isolated from Penicillium griseofulvum MCCC 3A00225, a deep sea-derived fungus. The structures of the new compounds were determined by detailed analysis of the NMR and HRESIMS spectroscopic data. The absolute configurations were established by X-ray crystallography, Marfey’s method, and the ICD method. All isolates were tested for in vitro anti-food allergic bioactivities in immunoglobulin (Ig) E-mediated rat basophilic leukemia (RBL)-2H3 cells. Compound 13 significantly decreased the degranulation release with an IC50 value of 60.3 μM, compared to that of 91.6 μM of the positive control, loratadine. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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