Diclofenac Sodium Adsorption onto Montmorillonite: Adsorption Equilibrium Studies and Drug Release Kinetics
| Autor: | Manpreet Kaur, Monika Datta |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: | |
| Zdroj: | Adsorption Science & Technology, Vol 32 (2014) |
| Druh dokumentu: | article |
| ISSN: | 0263-6174 2048-4038 |
| DOI: | 10.1260/0263-6174.32.5.365 |
| Popis: | The aim of the present work was to investigate the role of montmorillonite clay as an oral drug delivery carrier for in vitro controlled release of anti-inflammatory drug diclofenac sodium (DS). For this purpose, the adsorption behaviour of DS onto the clay was studied as a function of pH of the aqueous drug solution, contact time, initial drug concentration and clay dosage. The clay–drug composites synthesized were subsequently characterized by X-ray diffraction studies, Fourier transform-infrared studies, differential scanning calorimetric analysis, thermogravimetric analysis, zeta-potential measurement, scanning electron microscopic and high-resolution transmission electron microscopic techniques. A drug loading of 497 mg/g was obtained in case of intercalated clay–drug composite. The in vitro drug release studies of the synthesized clay–drug composites in simulated gastric fluid (pH 1.2) showed no release, whereas a prolonged drug release profile was obtained for the intercalated clay–drug composite in simulated intestinal fluid (phosphate-buffer saline 7.4) in comparison with the pristine drug. |
| Databáze: | Directory of Open Access Journals |
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