| Autor: |
Beom Seok Yoo, Cheol Wung Park, Jae-Kyun Jung, Jae-Eon Yoon, Tae-Yong An, Byung-Kwan Kim, Jin-Seong Lee |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
International Journal of Pain, Vol 15, Iss 1, Pp 19-27 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2233-4793 |
| DOI: |
10.56718/ijp.24-004 |
| Popis: |
Background : PF-72 (TGel Bio Co. Ltd., Seoul, Republic of Korea) is a type of temperature-responsive hydrogel. Methods : The eligible patients (n = 72) were randomized to either the trial group (n = 35; PF-72 mixed with 0.75% ropivacaine hydrochloride) or the control group (n = 37; patient-controlled anesthesia). We compared the amount of used rescue analgesics, numeric rating scale (NRS) pain scores, the cumulative area under the curve (AUC0-72) of NRS pain scores and incidences of treatment-emergent adverse events (TEAEs) and serious adverse events (SAEs). We estimated time-to-events (TTEs). Results : There were significant differences in the amount of used analgesics and NRS pain scores between the two groups at 3, 6, 24, 48 and 72 hours postoperatively (P = 0.000). There were also significant differences in AUC0-6, AUC0-24, AUC0-48 and AUC0-72 of NRS pain scores between the two groups (P = 0.000). There was a significant difference in the proportion of the patients presenting with no pain between the two groups at 3, 6 and 24 hours postoperatively (P = 0.000). There were no significant differences in the incidences of TEAEs and SAEs between the two groups (P > 0.05). TTEs are estimated at 7.486 ± 2.758 (95% confidence interval [CI] 2.081 ± 12.890) hr in the trial group and 9.324 ± 2.488 (95% CI 4.448 ± 14.200) hr in the control group. Conclusion : s: PF-72 mixed with 0.75% ropivacaine hydrochloride is an effective, safe modality in alleviating pain in the patients undergoing elective arthroscopic shoulder surgery. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
