| Autor: |
Inderjit Singh, Brooks P. Leitner, Yiwei Wang, Hanming Zhang, Phillip Joseph, Denyse D. Lutchmansingh, Mridu Gulati, Jennifer D. Possick, William Damsky, John Hwa, Paul M. Heerdt, Hyung J. Chun |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
Pulmonary Circulation, Vol 13, Iss 2, Pp n/a-n/a (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2045-8940 |
| DOI: |
10.1002/pul2.12220 |
| Popis: |
Abstract Approximately 50% of patients who recover from the acute SARS‐CoV‐2 experience Post Acute Sequelae of SARS‐CoV‐2 infection (PASC) syndrome. The pathophysiological hallmark of PASC is characterized by impaired system oxygen extraction (EO2) on invasive cardiopulmonary exercise test (iCPET). However, the mechanistic insights into impaired EO2 remain unclear. We studied 21 consecutive iCPET in PASC patients with unexplained exertional intolerance. PASC patients were dichotomized into mildly reduced (EO2peak‐mild) and severely reduced (EO2peak‐severe) EO2 groups according to the median peak EO2 value. Proteomic profiling was performed on mixed venous blood plasma obtained at peak exercise during iCPET. PASC patients as a group exhibited depressed peak exercise aerobic capacity (peak VO2; 85 ± 18 vs. 131 ± 45% predicted; p = 0.0002) with normal systemic oxygen delivery, DO2 (37 ± 9 vs. 42 ± 15 mL/kg/min; p = 0.43) and reduced EO2 (0.4 ± 0.1 vs. 0.8 ± 0.1; p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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