Stabilized Arylzinc Iodides in Negishi Acylative Cross-Coupling: A Modular Synthesis of Chalcones

Autor:	Michele Pierigé, Anna Iuliano, Gaetano Angelici, Gianluca Casotti
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	chalcones organozinc halides Negishi coupling cross-coupling acylative cross-coupling arylzinc halides Organic chemistry QD241-441
Zdroj:	Organics, Vol 3, Iss 2, Pp 87-94 (2022)
Druh dokumentu:	article
ISSN:	2673-401X
DOI:	10.3390/org3020006
Popis:	Stabilized arylzinc iodides, synthesized by direct insertion of zinc into the corresponding halides, were used as nucleophiles into an acylative Negishi coupling reaction to synthesize chalcones. The reaction conditions were optimized to afford optimal results on a model reaction and then applied to synthesize nine compounds. Esters, chlorides, electron-rich, electron-poor and sterically hindered substrates are well tolerated and even heteroaryl derivatives can be synthesized.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/564d63daac15462e90a8ef4d79f9dfb3 Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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