Intratumoral bacteria in uveal melanoma: A case report
| Autor: | Katherine Vega Escobar, Paola Ordonez Armijos, Tatyana Milman, Carol L. Shields, Ralph C. Eagle, Jr. |
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| Jazyk: | angličtina |
| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | American Journal of Ophthalmology Case Reports, Vol 30, Iss , Pp 101833- (2023) |
| Druh dokumentu: | article |
| ISSN: | 2451-9936 88135462 |
| DOI: | 10.1016/j.ajoc.2023.101833 |
| Popis: | Purpose: Intratumoral bacteria and their potential application to cancer immunotherapy have been a topic of interest in recent studies. To our knowledge, bacteria in uveal melanoma have not been previously reported. Observations: We describe a patient with a large choroidal melanoma, measuring 18 × 16 mm in basal dimension and 15 mm in ultrasonographic thickness, managed by plaque brachytherapy. At the time of plaque removal, a prophylactic scleral patch graft was placed to protect from anticipated scleral necrosis. Progressive ocular ischemia led to a blind and painful eye. The enucleated eye demonstrated an extensively necrotic and heavily pigmented mushroom-shaped regressed cilichoroidal mass deep to the scleral patch graft. Numerous Gram-positive cocci were noted within the regressed uveal melanoma and the adjacent sclera. Conclusions and Importance: This case highlights the fact that regressed uveal melanomas can contain intra-tumoral bacteria. |
| Databáze: | Directory of Open Access Journals |
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