Decreased heart dose with deep inspiration breath hold for the treatment of gastric lymphoma with IMRT

Autor: Kaitlin M. Christopherson, Jillian R. Gunther, Penny Fang, Stacy L. Peterson, Karen E. Roach, Pei-Fong Wong, Dragan Mirkovic, Tze Yee Lim, He Wang, Xin A Wang, Congjun Wang, John Garcia, Bouthaina S. Dabaja, Chelsea C. Pinnix
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Clinical and Translational Radiation Oncology, Vol 24, Iss , Pp 79-82 (2020)
Druh dokumentu: article
ISSN: 2405-6308
DOI: 10.1016/j.ctro.2020.05.013
Popis: We hypothesized that deep inspiration breath-hold (DIBH) and computed-tomography image-guided radiotherapy (CT-IGRT) may be beneficial to decrease dose to organs at risk (OARs), when treating the stomach with radiotherapy for lymphoma. We compared dosimetric parameters of OARs from plans generated using free-breathing (FB) versus DIBH for 10 patients with non-Hodgkin lymphoma involving the stomach treated with involved site radiotherapy. All patients had 4DCT and DIBH scans. Planning was performed with intensity modulated radiotherapy (IMRT) to 30.6 Gy in 17 fractions. Differences in target volume and dosimetric parameters were assessed using a paired two-sided t-test. All heart and left ventricle parameters including mean dose, V30, V20, V10, and V5 were statistically significantly lower with DIBH. For IMRT-FB plans the average mean heart dose was 4.9 Gy compared to 2.6 Gy for the IMRT-DIBH group (p
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