Pattern Recognition Receptors in Multiple Sclerosis and Its Animal Models

Autor:	M. Elizabeth Deerhake, Debolina D. Biswas, William E. Barclay, Mari L. Shinohara
Jazyk:	angličtina
Rok vydání:	2019
Předmět:	pattern recognition receptors (PRRs) multiple sclerosis (MS) experimental autoimmune encephalomyelitis (EAE) Toll-like receptors (TLRs) NOD-like receptors (NLRs) C-type lectin receptors (CLRs) Immunologic diseases. Allergy RC581-607
Zdroj:	Frontiers in Immunology, Vol 10 (2019)
Druh dokumentu:	article
ISSN:	1664-3224 56259786
DOI:	10.3389/fimmu.2019.02644
Popis:	Pattern recognition receptors (PRRs) coordinate the innate immune response and have a significant role in the development of multiple sclerosis (MS). Accumulating evidence has identified both pathogenic and protective functions of PRR signaling in MS and its animal model, experimental autoimmune encephalomyelitis (EAE). Additionally, evidence for PRR signaling in non-immune cells and PRR responses to host-derived endogenous ligands has also revealed new pathways controlling the development of CNS autoimmunity. Many PRRs remain uncharacterized in MS and EAE, and understanding the distinct triggers and functions of PRR signaling in CNS autoimmunity requires further investigation. In this brief review, we discuss the diverse pathogenic and protective functions of PRRs in MS and EAE, and highlight major avenues for future research.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/562597864f864ccb8d4e580e0d1c1de9 Zobrazit plný text záznamu View record in DOAJ