Assessment of the risk posed to Singapore by the emergence of artemisinin-resistant malaria in the Greater Mekong Subregion

Autor: Emma Xuxiao Zhang, Jean-Marc Chavatte, Cherie See Xin Yi, Charlene Tow, Wong Jia Ying, Kamran Khan, Olivia Seen Huey Oh, Sarah Ngeet Mei Chin, Khong Wei Xin, Zubaidah Said, Lyn James, Jeffery Cutter, Marc Ho, Jeannie Su Hui Tey
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Western Pacific Surveillance and Response, Vol 10, Iss 2, Pp 6-13 (2019)
Druh dokumentu: article
ISSN: 2094-7321
2094-7313
DOI: 10.5365/wpsar.2018.9.2.011
Popis: Objective: To assess the public health risk to Singapore posed by the emergence of artemisinin-resistant (ART-R) malaria in the Greater Mekong Subregion (GMS). Methods: We assessed the likelihood of importation of drug-resistant malaria into Singapore and the impact on public health of its subsequent secondary spread in Singapore. Literature on the epidemiology and contextual factors associated with ART-R malaria was reviewed. The epidemiology of malaria cases in Singapore was analysed. The vulnerability and receptivity of Singapore were examined, including the connectivity with countries reporting ART-R malaria, as well as the preparedness of Singaporean health authorities. Sources of information include international journals, World Health Organization guidelines, data from the Singapore Ministry of Health and National Public Health Laboratory of the National Centre for Infectious Diseases, and the International Air Transport Association. Results: The importation of ART-R malaria into Singapore is possible given the close proximity and significant travel volume between Singapore and the GMS countries reporting artemisinin resistance. Singapore’s vulnerability is further enhanced by the presence of foreign workers from neighbouring endemic countries. Nonetheless, the overall likelihood of such an event is low based on the rarity and decreasing trend of imported malaria incidence. With the presence of Anopheles vectors in Singapore, imported cases of drug-resistant malaria could cause secondary transmission. Nevertheless, the risk of sustained spread is likely to be mitigated by the comprehensive surveillance and control system in place for both infected vectors and human cases. Discussion: This risk assessment highlights the need for a continued high degree of vigilance of ART-R malaria locally and globally to minimize the risk and public health impact of drug-resistant malaria in Singapore.
Databáze: Directory of Open Access Journals
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