| Autor: |
Christina Kaprilian, Maria Horti, Kosmas Kandilaris, Andreas Skolarikos, Nikolaos Trakas, Ioannis Kastriotis, Charalambos Deliveliotis |
| Jazyk: |
angličtina |
| Rok vydání: |
2015 |
| Předmět: |
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| Zdroj: |
Journal of Kidney Cancer and VHL, Vol 2, Iss 1, Pp 25-29 (2015) |
| Druh dokumentu: |
article |
| ISSN: |
2203-5826 |
| DOI: |
10.15586/jkcvhl.2015.22 |
| Popis: |
Multidrug resistance correlates with unfavourable treatment outcomes in numerous cancers including renal cell carcinoma. The expression and clinical relevance of Glutathione-S-transferase-pi (GST-pi), a multidrug resistance factor, in kidney tumors remain controversial. We analyzed the expression of GST-pi in 60 formalin-fixed, paraffin-embedded renal cell carcinoma samples by immunohistochemistry and compared them with matched normal regions of the kidney. A significantly higher expression of GST-pi was observed in 87% of clear cell carcinoma and 50% of papillary subtypes. GST-pi expression did not correlate with tumor grade or patient survival. GST-pi is unlikely to be a prognostic factor for renal cell carcinoma. However, further studies with large number of samples are warranted to establish the role of GST-pi, if any, in intrinsic or acquired resistance of renal cell carcinoma to conventional treatments. Supplementary files: The supplementary files of this article are found under 'Article Tools' at the left side bar. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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