Clinical characteristics of patients with unexplainable hypothalamic disorder diagnosed by the corticotropin-releasing hormone challenge test: a retrospective study

Autor:	Yuji Hataya, Marie Okubo, Takuro Hakata, Kanta Fujimoto, Toshio Iwakura, Naoki Matsuoka
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	Central adrenal insufficiency Hypocortisolemia Corticotropin-releasing hormone challenge test Insulin tolerance test Myalgic encephalitis/chronic fatigue syndrome Diseases of the endocrine glands. Clinical endocrinology RC648-665
Zdroj:	BMC Endocrine Disorders, Vol 22, Iss 1, Pp 1-10 (2022)
Druh dokumentu:	article
ISSN:	1472-6823
DOI:	10.1186/s12902-022-01237-7
Popis:	Abstract Background The corticotropin-releasing hormone (CRH) challenge test can distinguish the disorders of the hypothalamus from those of the pituitary. However, the pathophysiology of hypothalamic disorder (HD) has not been fully understood. This study aimed to elucidate the clinical characteristics of patients with unexplainable HD, diagnosed by the CRH challenge test. Methods We retrospectively reviewed patients who underwent the CRH challenge test. Patients were categorized into four groups as follows: patients with peak serum cortisol ≥18 μg/dL were assigned to the normal response (NR) group (n = 18), among patients with peak serum cortisol
Databáze:	Directory of Open Access Journals
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