Intermittent hypoxic preconditioning reduces the risk of peri- and postoperative complications during on-pump cardiac surgery
| Autor: | I. Dhif, O. S. Glazachev, Af. A. Bestavashvili, Ch. Sinlyan, E. P. GulyaevaSeltsovskaya, N. O. Kuznetsova, E. A. Syrkina, V. V. Smirnova, E. N. Dudnik, P. Sh. Chomakhidze, B. M. Tlisov, R. N. Komarov, F. Yu. Kopylov |
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| Jazyk: | ruština |
| Rok vydání: | 2024 |
| Předmět: | |
| Zdroj: | Российский кардиологический журнал, Vol 29, Iss 7 (2024) |
| Druh dokumentu: | article |
| ISSN: | 1560-4071 2618-7620 |
| DOI: | 10.15829/1560-4071-2024-5778 |
| Popis: | Aim. To assess the effect of intermittent hypoxic-hyperoxic exposures (IHHE) on the outcomes of on-pump cardiac surgery.Material and methods. This prospective, single-center, randomized, controlled study was conducted in 110 patients with heart valve defects and/or aortic pathology from the cardiac surgery clinic of the I. M. Sechenov First Moscow State Medical University. The total sample was randomly divided into a group of patients who underwent IHHE (n=66) and a control group of patients who underwent placebo procedures with ambient air (n=44). The frequency and structure of intra-and postoperative complications were analyzed within 30 days after surgery. The presence of cognitive impairment, as well as serum troponin I and lactate concentrations were analyzed before and after surgery.Results. Peri- and early postoperative complications such as cardiac death, non-fatal infarction and acute heart failure occurred significantly less frequently in patients treated with IHHE compared with placebo group (1,6% vs 16,7%, p=0,009; 1,6% vs 16,7%, p=0,009; 6,3% vs 33,3%, p |
| Databáze: | Directory of Open Access Journals |
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